Challenging+Questions.

On this page, you can discuss topics that have emerged in the program.

1) **How do you measure forces between cells inside cell aggregates such as tumors**?

Forces of single cells on deformable substrates can be measured with accuracy. How do you extend this to single cells inside an aggregate of cells? Talk by Otger Campos

2) **What is the proper continuum description for normal cell tissue? For cancer tissue**?

In the homeostatic description tissue is treated as a highly compressible fluid. Stress relaxation takes place by cell division and cell death. If this is the right description for a fully developed tumor, how can the stress regulation be included that maintains organ structure and shape in normal tissue ? How do you include the acto-mysosin activity? Talks by Jacques Prost, Frank Julicher, Jens Elgeti, Boris Shraiman, Helene Delanoe-Ayari

3) **Statistical Noise of Expression Arrays**

Gene expression can be probed by RNA micro-arrays to locate mutations and post-translational modifications that play a central role in tumor progression. Statistical noise produces false correlations. Are there quantitative criteria that can be used to avoid this? Talks by Elke Markert, Eytan Domany, Jun Sung